Cells have to constantly adapt to their surroundings in order to survive. A sudden increase in the environmental levels of an osmolyte, such as salt, causes cells to lose water and shrink. In a matter of seconds, they activate a mechanism that allows them to recover their initial water volume and avoid dying.
Finding out which genes are involved in surviving osmotic stress was the subject of a study led by the laboratories of Dr. Posas and Dr. de Nadal at the Institute for Research in Biomedicine (IRB Barcelona) and Dr. Valverde at Pompeu Fabra University (UPF), in collaboration with a group led by Dr. Moffat from the University of Toronto (Canada). wide-genome genetic screening, the scientists discovered the central role of a gene known as LRRC8A in cellular ability to