Cassava Sciences Responds to Allegations that Data is Manipulated and “Defies Logic”

Western blot analysis

Alzheimer’s drug developer Cassava Sciences found its stock down by 19% in pre-market trading Wednesday morning, following allegations against the quality and integrity of its preclinical and clinical data made in a citizen petition to the U.S. Food and Drug Administration (FDA). The petition was posted on Monday by shareholder rights law firm Labaton Sucharow.  

Texas-based Cassava, whose mission is to develop innovative treatments for neurodegenerative conditions, is developing simufilam, an investigational small molecule drug that aims to restore the normal shape and function of altered scaffolding protein, filamin A (FLNA), in the brain.

Jordan Thomas, partner and chair of the whistleblower representation practice at Labaton Sucharow, requested that federal regulators put a halt to Cassava’s clinical trials, suggesting that some of the company’s results appeared to show signs of data manipulation.

“This report raises concerns about the quality and integrity of the laboratory-based studies surrounding this drug candidate,” the

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Escuela SMART Academy preparing for 1st day of school with new principal, new opportunities

The school’s new principal Natasha Allen has plans for students and their families to succeed in the Old South End community.

TOLEDO, Ohio — It’s back to class for Toledo Public Schools and students and their families had the chance to walk the halls before saying goodbye to summer.

The new school year brings something new to the bilingual multi-cultural school known as Escuela SMART Academy in the Old South End. 

And students were excited as they attended Tuesday’s open house. 

“I’m feeling very good and I hope that sooner or later they add football,” said Lemontray Davis, a 4th grader at Escuela SMART Academy. “And I hope I’m in Mrs. Fisher’s class!”

This year, the school will start with new opportunities and a brand new principal. 

“I feel like I’d be a good model for them and they can look up and see, ‘hey I can, I can be

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N.J. district may have game-changer for learning disruptions | Editorial

Many people in K-12 and special education circles are talking about “The Clayton Model (or “The Clayton Pilot”) as innovative and revolutionary.

Far fewer people, especially outside the ivory-tower loop that encircles education-policy academia, know that the reference is to the small Clayton Borough public school district in Gloucester County.

Briefly, the Clayton Model is what’s known in the trade as a social-emotional learning (SEL) program. In layman’s terms, SEL is a way of getting school to work for those with behavioral and other issues that can disrupt classes for all students, bring on disciplinary actions that are either unnecessary or too punitive, result in dubious special-education placements, and otherwise make things more difficult for students and instructors.

What’s different about the Clayton Model? First, it’s been around since 2008, when the district opened the Child Connection Center that administers this SEL program. Second, its resources (and the center) are

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Classic SF Featuring Planets With Very Long or Very Short Days

Earth is blessed with a day neither of extraordinary length nor of extreme brevity. Currently it is about twenty-four hours long. A quick glance at planets like Mercury and Venus shows us that worlds can have days much longer than Earth’s; bodies like Haumea suggest that days could be much shorter.

SF authors have notice this and written books about planets/planetesimals with different day lengths. Consider these five vintage works.

 

Mission of Gravity by Hal Clement (1953)

61 Cygni’s world Mesklin is sixteen times more massive than Jupiter. A day less than twenty minutes long means that the gravity at the equator is a measly three gravities. Thus, human starfarer Charles Lackland is able to briefly set down near the equator, where he is subjected to extreme discomfort (rather than immediate death). Too bad for Lackland that the object of his quest, a lost probe, is near one of Mesklin’s

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